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Cruise itinerary

16 night panama canal ocean to ocean holiday

Ask your friends: Should I go?

Ship: Island Princess (details)
Cruise line: Princess Cruises

Departure date: Friday, November 21, 2025
Return date: Sunday, December 07, 2025
Departure port: Ft. Lauderdale
Ports of call: Cartagena, Panama, Fuerte Amador, Puntarenas, Puerto Quetzal, Manzanillo
Return port: San Francisco

Prices:

Inside $1,299

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Outside $1,449

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Balcony $1,999

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Suite $3,149

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Cruiseable's travel advisors can often find you additional savings & lower fares than the public prices listed here.

Day Location

1
Ft. Lauderdale
2
Ft. Lauderdale
3
Cartagena
4
Panama
5
Fuerte Amador
6
Puntarenas
7
Puerto Quetzal
8
Manzanillo
9
San Francisco
10
San Francisco

One of San Francisco's iconic cable cars on California Street. The tradition dates back to 1873.

Grace Cathedral, an Episcopal cathedral in San Francisco's Huntington Park.

Ruby Princess docked at San Francisco's Pier 27 before an itinerary to the Mexican Riviera. You can see Coit Tower at the left.

Green heron near Quepos, Costa Rica.

The Church of St. Peter Claver is right next to old fortifications in Cartagena, Colombia.

The moon shines down on the San Francisco skyline in the early morming as seen from Treasure Island.

A view of the Transamerica pyramid in San Francisco.

Ruby Princess in Fort Lauderdale, Florida.

Blue-grey Tanager near Quepos, Costa Rica

Cartagena, Colombia, is a popular port on the Caribbean, due east of Panama.

The Conservatory of Flowers, a greenhouse and botanical garden that houses exotic plants in Golden Gate Park, San Francisco.

Rooftop view of San Francisco's Sunset district with the Golden Gate Bridge in the background.

A Central American Squirrel Monkey near Quepos, Costa Rica.

Grand Princess enters San Francisco Bay beneath the Golden Gate Bridge.

A 12th century Cambodian statue of Buddha at the Asian Art Museum in San Francisco.

We adore this closeup shot of San Francisco's Golden Gate Bridge at night.

A view of the lights along the Bay Bridge connecting San Francisco and Oakland.

Large iguana near the pool at Buena Vista, Quepos, Costa Rica.

Cannons on the Old City wall in Cartagena, Colombia.

Sunset on the Inland Waterway in Fort Lauderdale, Florida.