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Cruise itinerary

22 night complete mississippi river experience and land tour

Ask your friends: Should I go?

Ship: American Serenade (details)
Cruise line: American Cruise Lines

Departure date: Friday, June 12, 2026
Return date: Saturday, July 04, 2026
Departure port: New Orleans
Ports of call: River Cruising, Oak Alley, Houmas House, Baton Rouge, St. Francisville, Natchez, Vicksburg, Greenville, Tunica, Memphis, Cape Girardeau, St. Louis, Hannibal, Muscatine, Dubuque, Winona, Red Wing
Return port: St. Paul

Cruiseable's travel advisors can often find you additional savings & lower fares than the public prices listed here.

Day Location

1
New Orleans
2
New Orleans
3
River Cruising
4
Oak Alley
5
Houmas House
6
Baton Rouge
7
St. Francisville
8
Natchez
9
Vicksburg
10
Greenville
11
Tunica
12
Memphis
13
Cape Girardeau
14
River Cruising
15
St. Louis
16
River Cruising
17
Hannibal
18
River Cruising
19
Muscatine
20
Dubuque
21
River Cruising
22
Winona
23
Red Wing
24
St. Paul
25
St. Paul

Here's the rule: You can't visit New Orleans without trying beignets (pronounced ben-YAYS). A treat at Café du Monde on Decatur Street.

RTA Streetcar No. 2009 on Canal Street in New Orleans.

Shrimp and grits at Lüke Restaurant, St. Charles Avenue, New Orleans.

St. Louis Cathedral at Jackson Square in Vieux Carre, New Orleans.

Horse-drawn carriages pull up to Jackson Square in New Orleans.

Mule in the French Quarter, New Orleans.

A carriage ride in the French Quarter of New Orleans.