American Serenade has following cruise itineraries. Contact us for more information.

• 8 night lower mississippi river and land tour

  Starting in New Orleans

  Select

  2025 sails:

  Feb 21

  Feb 28

  Mar 07

  Mar 14

  Mar 21

  Mar 28

  Apr 04

  Apr 11

  Apr 18

  Apr 25

  May 02

  May 09

  May 16

  May 23

  May 30

  Jun 06

  Oct 16

  Oct 23

  Nov 09

  2026 sails:

  Feb 13

  Feb 20

  Feb 27

  Mar 06

  Mar 13

  Mar 20

  Mar 27

  Apr 03

  Apr 10

  Apr 17

  Apr 24

  May 01

  May 08

  May 15

  May 22

  May 29

  Jun 05

  Oct 15

  Oct 22

• 15 night grand heartland and land tour

  Starting in New Orleans

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  2025 sails:

  Sep 26

  2026 sails:

  Sep 25

• 7 night historic mississippi river and land tour

  Starting in New Orleans

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  2025 sails:

  Oct 10

  Nov 16

  2026 sails:

  Oct 09

  Nov 19

  Nov 25

  Dec 01

• 11 night mississippi explorer and land tour

  Starting in New Orleans

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  2025 sails:

  Oct 30

  2026 sails:

  Oct 29

  Nov 08

• 22 night complete mississippi river experience and land tour

  Starting in New Orleans

  Select

  2026 sails:

  Jun 12

• 8 night upper mississippi river

  Select

  2026 sails:

  Jul 10

  Jul 24

  Aug 07

  Aug 21

  Sep 04

  Sep 18